iS Clinical moisturizers are formulated with pharmaceutical-grade ingredients and high-grade botanicals to deliver targeted hydration while supporting the appearance of healthier, more resilient-looking skin. Whether you need lightweight daily moisture or intensive overnight repair, each moisturizer in this collection is designed to work within a professional-grade regimen.

Reparative Moisture Emulsion is a barrier-supporting moisturizer formulated with ceramides and peptides to help replenish and protect the skin's moisture barrier. Alongside Dynamic Daily Hydrator, it supports the appearance of smoother, more hydrated skin and provides versatile hydration options for a range of skin types. For intensive overnight support, Youth Intensive Creme delivers a rich, deeply nourishing formula designed to support the appearance of firmer, more youthful-looking skin while you sleep.

For lightweight daily hydration, Moisturizing Complex provides balanced moisture without heaviness, making it ideal for combination skin types. SHEALD Recovery Balm offers intensive barrier support for compromised or post-procedure skin, while Hydra-Intensive Cooling Masque delivers a concentrated hydration treatment for skin that needs an extra boost.

iS Clinical moisturizers represent the Hydrate step of the Cleanse, Treat, Hydrate, Protect regimen. Applied after treatment serums and before sun protection, these formulations seal in actives and support all-day hydration. Trusted by dermatologists and estheticians in 120+ countries.

Explore the full serums collection to pair with your moisturizer, or discover your ideal regimen with the skincare recommendation quiz.