Best Sellers

The best iS Clinical products represent the most trusted formulations in the collection — professional-grade skincare chosen by dermatologists, estheticians, and consumers worldwide. Each best seller in this collection has earned its reputation through clinically proven results and pharmaceutical-grade ingredients that deliver visible benefits.

Active Serum leads the collection as the brand's most iconic treatment serum. This multi-concern formula combines botanically derived acids with powerful antioxidants to visibly refine skin texture and support a clearer-looking complexion. Paired with Cleansing Complex, the collection's top-selling cleanser, these two products form the foundation of a professional-grade regimen.

For targeted antioxidant support, Pro-Heal Serum Advance+ delivers a new generation of L-Ascorbic Acid with Olive Leaf Extract — a Vitamin C serum trusted by skincare professionals for supporting the appearance of calm, resilient-looking skin. Reparative Moisture Emulsion provides barrier-supporting hydration with ceramides and peptides, while Eclipse SPF 50+ rounds out the collection with lightweight mineral sun protection.

These best sellers span every step of the Cleanse, Treat, Hydrate, Protect regimen — making it easy to build a complete, professional-grade skincare routine from the most proven formulations in the line. Trusted by professionals in 120+ countries.

Discover your ideal regimen with the skincare recommendation quiz, or explore the full serums collection for additional treatment options.