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Receive a complimentary Hydra-Cool Serum® Deluxe Mini (0.16 oz 5 mL) with purchases of $175 or more. Use code AUGGIFT26 at checkout. Details

Anti-Aging

  • Super Serum Advance+ - iS CLINICAL Super Serum Advance+ - iS CLINICAL
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    Super Serum Advance+

    Regular price $177.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Super Serum Advance+

    RESTORATIVE, SUPER ANTIOXIDANT, REPARATIVE

    Regular price $104.00 – $177.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Active Serum - iS CLINICAL Active Serum - iS CLINICAL
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    Active Serum

    Regular price $155.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Active Serum

    AGE-DEFYING, CLEARING, BRIGHTENING

    Regular price $96.00 – $155.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details

  • DISCOVER NOW
  • Youth Intensive Crème - iS CLINICAL Youth Intensive Crème - iS CLINICAL

    Youth Intensive Crème

    Regular price $256.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    Youth Intensive Crème

    AGE-DEFYING, HYDRATING, FIRMING

    Regular price $256.00 – $420.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Youth Eye Complex - iS CLINICAL Youth Eye Complex - iS CLINICAL
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    Youth Eye Complex

    Regular price $125.00
    Size: Net wt. 0.5 oz e 15 g
    STEP 2: TREAT

    Youth Eye Complex

    Hydrating Eye Cream to Reduce the Appearance of Fine Lines & Wrinkles

    Regular price $125.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Youth Complex - iS CLINICAL Youth Complex - iS CLINICAL

    Youth Complex

    Regular price $172.00
    Size: Net wt. 1 oz. e 30 g
    STEP 2: TREAT

    Youth Complex

    TONING, AGE-DEFYING, TIGHTENING

    Regular price $172.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Brightening Complex - iS CLINICAL Brightening Complex - iS CLINICAL

    Brightening Complex

    Regular price $166.00
    Size: Net wt. 1 oz. e 30 g
    STEP 2: TREAT

    Brightening Complex

    SAFE BRIGHTENING, HYDRATING, ANTIOXIDANT

    Regular price $166.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • GeneXC Serum - iS CLINICAL GeneXC Serum - iS CLINICAL

    GeneXC Serum

    Regular price $185.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    GeneXC Serum

    PROTECTIVE, RESTORATIVE, AGE-DEFYING

    Regular price $114.00 – $185.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Youth Serum - iS CLINICAL Youth Serum - iS CLINICAL

    Youth Serum

    Regular price $174.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Youth Serum

    TIGHTENING, SMOOTHING, RESTORATIVE

    Regular price $174.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details

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  • Retinol+ Emulsion 0.3 - iS CLINICAL Retinol+ Emulsion 0.3 - iS CLINICAL
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    Retinol+ Emulsion 0.3

    Regular price $117.00
    Size: Net wt. 1 oz e 30 g
    STEP 2: TREAT

    Retinol+ Emulsion 0.3

    AGE-DEFYING, SMOOTHING, BRIGHTENING

    Regular price $117.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Daily Dynamic Hydrator - iS CLINICAL Daily Dynamic Hydrator
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    Daily Dynamic Hydrator

    Regular price $135.00
    Size: Net wt. 1.7 oz e 50 g
    STEP 3: HYDRATE

    Daily Dynamic Hydrator

    HYDRATING, DEFENDING, RENEWING

    Regular price $52.00 – $135.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Cleansing Complex - iS CLINICAL Cleansing Complex - iS CLINICAL
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    Cleansing Complex

    Regular price $49.00
    Size: 6 fl. oz. e 180 mL
    STEP 1: CLEANSE

    Cleansing Complex

    RESURFACING, CLEARING, DEEP-CLEANSING

    Regular price $27.00 – $49.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Reparative Moisture Emulsion - iS CLINICAL Reparative Moisture Emulsion - iS CLINICAL
    Best Seller

    Reparative Moisture Emulsion

    Regular price $116.00
    Size: Net wt. 1.7oz e 50 g
    STEP 3: HYDRATE

    Reparative Moisture Emulsion

    RESTORING, HYDRATING, SMOOTHING

    Regular price $116.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • C Eye Serum Advance+ - iS CLINICAL C Eye Serum Advance+ - iS CLINICAL

    C Eye Serum Advance+

    Regular price $75.00
    Size: 15 g e Net wt. 0.5 oz
    STEP 2: TREAT

    C Eye Serum Advance+

    Vitamin C Eye Serum to Brighten & Reduce Visible Signs of Aging

    Regular price $75.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Firming Complex - iS CLINICAL Firming Complex - iS CLINICAL

    Firming Complex

    Regular price $148.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    Firming Complex

    AGE-DEFYING, FIRMING, REFINING

    Regular price $148.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Extreme Protect SPF 30 - iS CLINICAL Extreme Protect SPF 30 - iS CLINICAL
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    Extreme Protect SPF 30

    Regular price $86.00
    Size: Net wt. 3.5 oz.e 100 g
    STEP 4: PROTECT

    Extreme Protect SPF 30

    HYDRATING, RESTORATIVE, UVA/UVB PROTECTION

    Regular price $53.00 – $86.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Extreme Protect SPF 40 - iS CLINICAL Extreme Protect SPF 40 - iS CLINICAL

    Extreme Protect SPF 40

    Regular price $92.00
    Size: Net wt. 3.5 oz. e 100 g
    Tint: Translucent
    STEP 4: PROTECT

    Extreme Protect SPF 40

    ULTRA SHEER, BROAD SPECTRUM, SPF 50+

    Regular price $92.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Eclipse SPF 50+ - iS CLINICAL Eclipse SPF 50+ - iS CLINICAL

    Eclipse SPF 50+

    Regular price $54.00
    Size: Net wt. 3.5 oz. e 100 g
    Tint: Translucent
    STEP 4: PROTECT

    Eclipse SPF 50+

    ULTRA SHEER, BROAD SPECTRUM, SPF 50+

    Regular price $54.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Cream Cleanser - iS CLINICAL Cream Cleanser - iS CLINICAL

    Cream Cleanser

    Regular price $52.00
    Size: 4 fl. oz. e 120 mL
    STEP 1: CLEANSE

    Cream Cleanser

    DEEP-CLEANSING, MOISTURIZING, SOOTHING

    Regular price $52.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Eye Complex - iS CLINICAL Eye Complex - iS CLINICAL

    Eye Complex

    Regular price $98.00
    Size: Net wt. 0.5 oz e 15 g
    STEP 2: TREAT

    Eye Complex

    Smoothing Eye Cream to Reduce the Look of Puffiness & Dark Circles

    Regular price $98.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • LIProtect SPF 35 - iS CLINICAL LIProtect SPF 35 - iS CLINICAL

    LIProtect SPF 35

    Regular price $25.00
    Size: Net wt. 0.17oz e 5 g
    STEP 4: PROTECT

    LIProtect SPF 35

    PROTECTIVE, NOURISHING, CONDITIONING

    Regular price $25.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • PerfecTint Powder SPF 40 - iS CLINICAL PerfecTint Powder SPF 40 - iS CLINICAL

    PerfecTint Powder SPF 40

    Regular price $82.00
    Size: Boxed Set
    Tint: PerfecTint Ivory
    STEP 4: PROTECT

    PerfecTint Powder SPF 40

    TOTAL PROTECTION, HYDRATING, MATTE FINISH

    Regular price $82.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Moisturizing Complex - iS CLINICAL Moisturizing Complex - iS CLINICAL
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    Moisturizing Complex

    Regular price $106.00
    Size: Net wt. 1.7oz e 50 g
    STEP 3: HYDRATE

    Moisturizing Complex

    HYDRATING, SOOTHING, PROTECTING

    Regular price $106.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Youth Body Serum - iS CLINICAL Youth Body Serum - iS CLINICAL
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    Youth Body Serum

    Regular price $130.00
    Size: 6.7 fl. oz. e 200 mL
    STEP 2: TREAT

    Youth Body Serum

    HYDRATING, NOURISHING, PROTECTIVE

    Regular price $29.00 – $130.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • NeckPerfect Complex - iS CLINICAL NeckPerfect Complex - iS CLINICAL
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    NeckPerfect Complex

    Regular price $120.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    NeckPerfect Complex

    TIGHTENING, SCULPTING, SMOOTHING

    Regular price $120.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Copper Firming Mist - iS CLINICAL Copper Firming Mist - iS CLINICAL
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    Copper Firming Mist

    Regular price $45.00
    Size: 2.5 fl. oz. e 75 mL
    STEP 2: TREAT

    Copper Firming Mist

    AGE-DEFYING, REFRESHING, FIRMING

    Regular price $45.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Pure Renewal Collection - iS CLINICAL Pure Renewal Collection - iS CLINICAL
    24% Savings

    Pure Renewal Collection

    Regular price $288.00
    (24% Savings)
    Size: Boxed Set

    Pure Renewal Collection

    Regular price $288.00
    (24% Savings)

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • Poly - Vitamin Serum - iS CLINICAL Poly - Vitamin Serum - iS CLINICAL

    Poly-Vitamin Serum

    Regular price $125.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Poly-Vitamin Serum

    REVITALIZING, HYDRATING, AGE-DEFYING

    Regular price $78.00 – $125.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details
  • GeneXC Firming Eye Gel - iS CLINICAL GeneXC Firming Eye Gel - iS CLINICAL
    New

    GeneXC Firming Eye Gel

    Regular price $130.00
    STEP 2: TREAT

    GeneXC Firming Eye Gel

    Firming Eye Gel with Vitamin C & Peptides for Fast-Acting Radiance

    Regular price $130.00

    Free Hydra-Cool Serum® Deluxe Mini (0.16 oz. 5 mL) on $175+ orders. Code: AUGGIFT26. Details

iS Clinical anti-aging products are formulated with pharmaceutical-grade ingredients to target the visible signs of aging — including the appearance of fine lines, loss of firmness, and uneven texture. Each product in this collection combines clinically proven actives with high-grade botanicals for visible results backed by science.

Super Serum Advance+ is the collection's advanced anti-aging serum, delivering potent antioxidants to support the appearance of firmer, smoother-looking skin. This concentrated formula is designed for consumers seeking visible improvement in skin texture and resilience. For a multi-concern approach, Active Serum addresses the appearance of fine lines, uneven texture, and congested skin in one versatile formula trusted by skincare professionals worldwide.

Retinoid support is available through Retinol+ Emulsion 0.3, a stabilized retinol formula delivering a safe and effective growth factor analog designed for visible skin renewal while minimizing the irritation commonly associated with retinol use. For intensive overnight nourishment, Youth Intensive Creme delivers a rich formula that supports the appearance of firmer, more youthful-looking skin while you sleep. Additional targeted options include Youth Body Serum for lightweight daily support and Body Complex for body-focused firming.

iS Clinical anti-aging formulations span the Treat and Hydrate steps of the Cleanse, Treat, Hydrate, Protect regimen. Trusted by dermatologists and estheticians in 120+ countries.

Explore the full serums collection for treatment options, or discover your ideal regimen with the skincare recommendation quiz.