Treat

  • Poly - Vitamin Serum - iS CLINICAL Poly - Vitamin Serum - iS CLINICAL

    Poly-Vitamin Serum

    Regular price $125.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Poly-Vitamin Serum

    REVITALIZING, HYDRATING, AGE-DEFYING

    Regular price $78.00 – $125.00
  • Hydra - Intensive Cooling Masque - iS CLINICAL Hydra - Intensive Cooling Masque - iS CLINICAL

    Hydra-Intensive Cooling Masque

    Regular price $105.00
    Size: Net wt. 4 oz. e 120 g
    STEP 2: TREAT

    Hydra-Intensive Cooling Masque

    REINVIGORATING, REFRESHING, SOOTHING

    Regular price $105.00
  • Lip Polish - iS CLINICAL Lip Polish - iS CLINICAL
    Award Winner

    Lip Polish

    Regular price $40.00
    Size: Net wt. 0.5 oz e 15 g
    STEP 2: TREAT

    Lip Polish

    SMOOTHING, RENEWING, HYDRATING

    Regular price $40.00
  • Tri - Active Exfoliating Masque - iS CLINICAL Tri - Active Exfoliating Masque - iS CLINICAL

    Tri-Active Exfoliating Masque

    Regular price $104.00
    Size: Net wt. 4 oz. e 120 g
    STEP 2: TREAT

    Tri-Active Exfoliating Masque

    AGE-DEFYING, RESURFACING, SMOOTHING

    Regular price $104.00
  • Body Complex - iS CLINICAL Body Complex - iS CLINICAL

    Body Complex

    Regular price $79.00
    Size: Net wt. 6 oz. e 180 g
    STEP 2: TREAT

    Body Complex

    SOOTHING, SMOOTHING, PROTECTIVE

    Regular price $79.00
  • Youth Body Serum - iS CLINICAL Youth Body Serum - iS CLINICAL
    Award Winner

    Youth Body Serum

    Regular price $130.00
    Size: 6.7 fl. oz. e 200 mL
    STEP 2: TREAT

    Youth Body Serum

    HYDRATING, NOURISHING, PROTECTIVE

    Regular price $29.00 – $130.00
  • Extra Strength Active Peel Brightening System - iS CLINICAL Extra Strength Active Peel Brightening System - iS CLINICAL
    Award Winner

    Extra Strength Active Peel Brightening System

    Regular price $120.00
    Size: 15 Treatment Sets per Box
    STEP 2: TREAT

    Extra Strength Active Peel Brightening System

    Regular price $120.00
  • Copper Firming Mist - iS CLINICAL Copper Firming Mist - iS CLINICAL
    Award Winner

    Copper Firming Mist

    Regular price $45.00
    Size: 2.5 fl. oz. e 75 mL
    STEP 2: TREAT

    Copper Firming Mist

    AGE-DEFYING, REFRESHING, FIRMING

    Regular price $45.00
  • Sheald Recovery Balm - iS CLINICAL Sheald Recovery Balm - iS CLINICAL
    Best Seller

    Sheald Recovery Balm

    Regular price $89.00
    Size: Net wt. 2 oz. 60 g
    STEP 2: TREAT

    Sheald Recovery Balm

    PROTECTIVE, SOOTHING, NOURISHING

    Regular price $34.00 – $89.00
  • Youth Intensive Crème - iS CLINICAL Youth Intensive Crème - iS CLINICAL

    Youth Intensive Crème

    Regular price $256.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    Youth Intensive Crème

    AGE-DEFYING, HYDRATING, FIRMING

    Regular price $256.00 – $420.00

iS Clinical treatment products represent the most active step in the Cleanse, Treat, Hydrate, Protect regimen — delivering pharmaceutical-grade serums, eye care, and targeted formulations that address specific skin concerns at clinically effective concentrations. The Treat step is where visible transformation happens, with concentrated actives designed to support the appearance of smoother, firmer, and more radiant-looking skin.

Serums form the core of the Treat step. Active Serum is the brand's most versatile treatment, combining botanically derived acids with potent antioxidants to visibly refine texture and support a clearer-looking complexion. For advanced anti-aging support, Super Serum Advance+ delivers plant-derived growth factor analog that support the appearance of firmer, smoother-looking skin. Pro-Heal Serum Advance+ provides pharmaceutical-grade Vitamin C with Olive Leaf Extract for antioxidant support and calming benefits.

Additional treatment options include Hydra-Cool Serum for lightweight hydration with Hyaluronic Acid, Brightening Serum for targeting the appearance of uneven tone, and Retinol+ Emulsion 0.3 for stabilized retinoid renewal. Eye-specific treatments like C Eye Serum Advance+ and exfoliating treatments like Tri-Active Exfoliating Masque also belong in this step.

Apply treatment products after cleansing and before moisturizer for optimal absorption. Layer lighter serums first, followed by richer formulations. Trusted by professionals in 60+ countries.

Explore specific treatment categories: serums, eye care, or exfoliants. Discover your ideal regimen with the skincare recommendation quiz.