iS Clinical anti-aging products are formulated with pharmaceutical-grade ingredients to target the visible signs of aging — including the appearance of fine lines, loss of firmness, and uneven texture. Each product in this collection combines clinically proven actives with high-grade botanicals for visible results backed by science.

Super Serum Advance+ is the collection's advanced anti-aging serum, delivering potent antioxidants to support the appearance of firmer, smoother-looking skin. This concentrated formula is designed for consumers seeking visible improvement in skin texture and resilience. For a multi-concern approach, Active Serum addresses the appearance of fine lines, uneven texture, and congested skin in one versatile formula trusted by skincare professionals worldwide.

Retinoid support is available through Retinol+ Emulsion 0.3, a stabilized retinol formula delivering a safe and effective growth factor analog designed for visible skin renewal while minimizing the irritation commonly associated with retinol use. For intensive overnight nourishment, Youth Intensive Creme delivers a rich formula that supports the appearance of firmer, more youthful-looking skin while you sleep. Additional targeted options include Youth Body Serum for lightweight daily support and Body Complex for body-focused firming.

iS Clinical anti-aging formulations span the Treat and Hydrate steps of the Cleanse, Treat, Hydrate, Protect regimen. Trusted by dermatologists and estheticians in 120+ countries.

Explore the full serums collection for treatment options, or discover your ideal regimen with the skincare recommendation quiz.