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  • Youth Body Serum - iS CLINICAL Youth Body Serum - iS CLINICAL
    Award Winner

    Youth Body Serum

    Regular price $130.00
    Size: 6.7 fl. oz. e 200 mL
    STEP 2: TREAT

    Youth Body Serum

    HYDRATING, NOURISHING, PROTECTIVE

    Regular price $29.00 – $130.00
  • Hydra - Intensive Cooling Masque - iS CLINICAL Hydra - Intensive Cooling Masque - iS CLINICAL

    Hydra-Intensive Cooling Masque

    Regular price $105.00
    Size: Net wt. 4 oz. e 120 g
    STEP 2: TREAT

    Hydra-Intensive Cooling Masque

    REINVIGORATING, REFRESHING, SOOTHING

    Regular price $105.00
  • Pure Calm Collection - iS CLINICAL Pure Calm Collection - iS CLINICAL
    22% Savings

    Pure Calm Collection

    Regular price $219.00
    (22% Savings)
    Size: Boxed Set

    Pure Calm Collection

    Regular price $219.00
    (22% Savings)
  • PerfecTint Powder SPF 40 - iS CLINICAL PerfecTint Powder SPF 40 - iS CLINICAL

    PerfecTint Powder SPF 40

    Regular price $82.00
    Size: Boxed Set
    Tint: PerfecTint Ivory
    STEP 4: PROTECT

    PerfecTint Powder SPF 40

    TOTAL PROTECTION, HYDRATING, MATTE FINISH

    Regular price $82.00
  • Pure Care Collection - iS CLINICAL Pure Care Collection - iS CLINICAL
    6% Savings

    Pure Care Collection

    Regular price $108.00
    (6% Savings)
    Size: Boxed Set

    Pure Care Collection

    Regular price $108.00
    (6% Savings)
  • Poly - Vitamin Serum - iS CLINICAL Poly - Vitamin Serum - iS CLINICAL

    Poly-Vitamin Serum

    Regular price $125.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Poly-Vitamin Serum

    REVITALIZING, HYDRATING, AGE-DEFYING

    Regular price $78.00 – $125.00
  • Body Complex - iS CLINICAL Body Complex - iS CLINICAL

    Body Complex

    Regular price $79.00
    Size: Net wt. 6 oz. e 180 g
    STEP 2: TREAT

    Body Complex

    SOOTHING, SMOOTHING, PROTECTIVE

    Regular price $79.00
  • Pure Clarity Collection - iS CLINICAL Pure Clarity Collection - iS CLINICAL
    23% Savings

    Pure Clarity Collection

    Regular price $209.00
    (23% Savings)
    Size: Boxed Set

    Pure Clarity Collection

    Regular price $209.00
    (23% Savings)
  • Lip Polish - iS CLINICAL Lip Polish - iS CLINICAL
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    Lip Polish

    Regular price $40.00
    Size: Net wt. 0.5 oz e 15 g
    STEP 2: TREAT

    Lip Polish

    SMOOTHING, RENEWING, HYDRATING

    Regular price $40.00
  • Firming Complex - iS CLINICAL Firming Complex - iS CLINICAL

    Firming Complex

    Regular price $148.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    Firming Complex

    AGE-DEFYING, FIRMING, REFINING

    Regular price $148.00
  • Balance and Hydrate Duo Holiday Kit - iS CLINICAL Balance and Hydrate Duo Holiday Kit - iS CLINICAL
    22% Savings

    Balance and Hydrate Duo Holiday Kit

    Regular price $90.00

    Balance and Hydrate Duo Holiday Kit

    Regular price $90.00
  • Warm Up, Cool Down - iS CLINICAL Warm Up, Cool Down - iS CLINICAL
    20% Savings

    Warm Up, Cool Down

    Regular price $125.00
    (20% Savings)
    Size: Boxed Set

    Warm Up, Cool Down

    Regular price $125.00
    (20% Savings)
  • Pure Renewal Collection - iS CLINICAL Pure Renewal Collection - iS CLINICAL
    24% Savings

    Pure Renewal Collection

    Regular price $288.00
    (24% Savings)
    Size: Boxed Set

    Pure Renewal Collection

    Regular price $288.00
    (24% Savings)
  • Smooth & Soothe - iS CLINICAL Smooth & Soothe - iS CLINICAL
    21% Savings

    Smooth & Soothe

    Regular price $164.00
    (21% Savings)
    Size: Boxed Set

    Smooth & Soothe

    Regular price $164.00
    (21% Savings)
  • Smoothing Essentials Holiday Kit - iS CLINICAL Smoothing Essentials Holiday Kit - iS CLINICAL
    26% Savings

    Smoothing Essentials Holiday Kit

    Regular price $215.00

    Smoothing Essentials Holiday Kit

    Regular price $215.00
  • Pure Radiance Collection - iS CLINICAL Pure Radiance Collection - iS CLINICAL
    24% Savings

    Pure Radiance Collection

    Regular price $278.00
    (24% Savings)
    Size: Boxed Set

    Pure Radiance Collection

    Regular price $278.00
    (24% Savings)

iS Clinical products represent the intersection of pharmaceutical-grade science and luxury skincare — delivering clinically proven formulations trusted by professionals in 120+ countries. This complete collection brings together the full range of cleansers, treatment serums, moisturizers, sun protection, and specialty products within the Cleanse, Treat, Hydrate, Protect regimen.

Start with the Cleanse step, where Cleansing Complex prepares the skin for optimal absorption of treatment actives. Move to the Treat step with targeted serums like Active Serum and Pro-Heal Serum Advance+ to address specific complexion concerns. The Hydrate step seals in moisture with products like Reparative Moisture Emulsion, and the Protect step completes the regimen with Eclipse SPF 50+ for daily sun defense.

Beyond the core regimen, explore specialty categories including eye care, body treatments, and exfoliants for comprehensive results from head to toe. Every iS Clinical formulation is developed with botanically derived actives and backed by clinical research.

Find your ideal protocol with the skincare recommendation quiz, or explore our best sellers to discover the products professionals recommend most.