The Cleanse step is the essential foundation of the iS Clinical Cleanse, Treat, Hydrate, Protect regimen. iS Clinical cleansing products are formulated with pharmaceutical-grade ingredients that go beyond basic surface cleansing — preparing the skin for optimal absorption of the treatment actives that follow while supporting the appearance of a refined, clearer-looking complexion.

Cleansing Complex anchors this step as the brand's best-selling cleanser. Its resurfacing formula with botanically sourced acids and gentle acids supports the appearance of smoother, more clarified skin from the very first step. For a deeper exfoliating cleanse, Cleansing Complex Polish adds micro-polishing beads to the same formula for enhanced resurfacing.

Consumers seeking a nourishing cleansing experience will find Warming Honey Cleanser delivers a unique warming sensation with honey and vitamin E for gentle exfoliation and softer-looking skin. For dry or sensitive skin, Cream Cleanser provides a hydrating, non-foaming formula that effectively removes impurities without stripping the skin's natural moisture barrier.

Cleansing both morning and evening ensures your skin is prepared for the treatment products that follow. A thorough yet gentle cleanse sets the stage for serums, moisturizers, and sun protection to perform at their best. Trusted by professionals in 120+ countries.

Continue your regimen with the Treat step, or discover your ideal cleansing protocol with the skincare recommendation quiz.