EXCLUSIVE GIFT WITH PURCHASE

EXCLUSIVE GIFT WITH PURCHASE

Receive a complimentary Daily Must-Haves Set ($112 Value) with purchases of $225 or more. Use code SEPGIFT26 at checkout. Details

Shop All

Shop clinically proven cleansers, serums, moisturizers, treatments and more, for your healthiest skin yet.

  • Daily Active Smoothing Toner - iS CLINICAL Daily Active Smoothing Toner - iS CLINICAL
    New

    Daily Active Smoothing Toner

    Regular price $52.00
    Size: 6 fl. oz. e 180 mL
    STEP 1: TONE

    Daily Active Smoothing Toner

    Multi-Acid Exfoliating Toner for Smooth, Balanced, Glowing Skin

    Regular price $52.00

    LAUNCH GIFT: First 500 purchases receive a travel-size Cleansing Complex ($27 value). Details
  • Cleansing Complex - iS CLINICAL Cleansing Complex - iS CLINICAL
    Award Winner

    Cleansing Complex

    Regular price $49.00
    Size: 6 fl. oz. e 180 mL
    STEP 1: CLEANSE

    Cleansing Complex

    RESURFACING, CLEARING, DEEP-CLEANSING

    Regular price $27.00 – $49.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details

  • Discover Now
  • Pro - Heal Serum Advance+ - iS CLINICAL Pro - Heal Serum Advance+ - iS CLINICAL
    Best Seller

    Pro-Heal Serum Advance+

    Regular price $177.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Pro-Heal Serum Advance+

    RESTORATIVE, REVITALIZING, POWERFUL ANTIOXIDANT BLEND

    Regular price $104.00 – $177.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details

  • Discover Now
  • Reparative Moisture Emulsion - iS CLINICAL Reparative Moisture Emulsion - iS CLINICAL
    Best Seller

    Reparative Moisture Emulsion

    Regular price $116.00
    Size: Net wt. 1.7oz e 50 g
    STEP 3: HYDRATE

    Reparative Moisture Emulsion

    RESTORING, HYDRATING, SMOOTHING

    Regular price $116.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Active Serum - iS CLINICAL Active Serum - iS CLINICAL
    Best Seller

    Active Serum

    Regular price $155.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Active Serum

    RENEWING, CLEARING, BRIGHTENING

    Regular price $96.00 – $155.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Hydra - Cool Serum - iS CLINICAL Hydra - Cool Serum - iS CLINICAL
    Award Winner

    Hydra-Cool Serum

    Regular price $108.00
    Size: 1 fl. oz. e 30 mL
    STEP 3: HYDRATE

    Hydra-Cool Serum

    HYDRATING, SOOTHING, CLEARING

    Regular price $70.00 – $108.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Active Peel System - iS CLINICAL Active Peel System - iS CLINICAL
    Best Seller

    Active Peel System

    Regular price $99.00
    Size: 15 Treatment Sets per Box
    STEP 2: TREAT

    Active Peel System

    AGE-DEFYING, EXFOLIATING, REJUVENATING

    Regular price $99.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details

  • SHOP NOW
  • Daily Dynamic Hydrator - iS CLINICAL Daily Dynamic Hydrator
    Award Winner

    Daily Dynamic Hydrator

    Regular price $135.00
    Size: Net wt. 1.7 oz e 50 g
    STEP 3: HYDRATE

    Daily Dynamic Hydrator

    HYDRATING, DEFENDING, RENEWING

    Regular price $52.00 – $135.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details

  • SHOP NOW
  • Youth Eye Complex - iS CLINICAL Youth Eye Complex - iS CLINICAL
    Best Seller

    Youth Eye Complex

    Regular price $125.00
    Size: Net wt. 0.5 oz e 15 g
    STEP 2: TREAT

    Youth Eye Complex

    Hydrating Eye Cream to Reduce the Appearance of Fine Lines & Wrinkles

    Regular price $125.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Super Serum Advance+ - iS CLINICAL Super Serum Advance+ - iS CLINICAL
    Award Winner

    Super Serum Advance+

    Regular price $177.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Super Serum Advance+

    RESTORATIVE, SUPER ANTIOXIDANT, REPARATIVE

    Regular price $104.00 – $177.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Eclipse SPF 50+ - iS CLINICAL Eclipse SPF 50+ - iS CLINICAL

    Eclipse SPF 50+

    Regular price $54.00
    Size: Net wt. 3.5 oz. e 100 g
    Tint: Translucent
    STEP 4: PROTECT

    Eclipse SPF 50+

    ULTRA SHEER, BROAD SPECTRUM, SPF 50+

    Regular price $54.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Retinol+ Emulsion 0.3 - iS CLINICAL Retinol+ Emulsion 0.3 - iS CLINICAL
    Award Winner

    Retinol+ Emulsion 0.3

    Regular price $117.00
    Size: Net wt. 1 oz e 30 g
    STEP 2: TREAT

    Retinol+ Emulsion 0.3

    AGE-DEFYING, SMOOTHING, BRIGHTENING

    Regular price $117.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Sheald Recovery Balm - iS CLINICAL Sheald Recovery Balm - iS CLINICAL
    Best Seller

    Sheald Recovery Balm

    Regular price $89.00
    Size: Net wt. 2 oz. 60 g
    STEP 2: TREAT

    Sheald Recovery Balm

    PROTECTIVE, SOOTHING, NOURISHING

    Regular price $34.00 – $89.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Moisturizing Complex - iS CLINICAL Moisturizing Complex - iS CLINICAL
    Best Seller

    Moisturizing Complex

    Regular price $106.00
    Size: Net wt. 1.7oz e 50 g
    STEP 3: HYDRATE

    Moisturizing Complex

    HYDRATING, SOOTHING, PROTECTING

    Regular price $106.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • GeneXC Firming Eye Gel - iS CLINICAL GeneXC Firming Eye Gel - iS CLINICAL
    New

    GeneXC Firming Eye Gel

    Regular price $130.00
    STEP 2: TREAT

    GeneXC Firming Eye Gel

    Firming Eye Gel with Vitamin C & Peptides for Fast-Acting Radiance

    Regular price $130.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Warming Honey Cleanser - iS CLINICAL Warming Honey Cleanser - iS CLINICAL

    Warming Honey Cleanser

    Regular price $52.00
    Size: 4 fl. oz. e 120 mL
    STEP 1: CLEANSE

    Warming Honey Cleanser

    DEEP-CLEANSING, MOISTURIZING, SOOTHING

    Regular price $52.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Cleansing Complex Polish - iS CLINICAL Cleansing Complex Polish - iS CLINICAL
    Best Seller

    Cleansing Complex Polish

    Regular price $52.00
    Size: Net wt. 4 oz. e 120 g
    STEP 1: CLEANSE

    Cleansing Complex Polish

    DEEP-CLEANSING, RESURFACING, SMOOTHING

    Regular price $52.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Extreme Protect SPF 30 - iS CLINICAL Extreme Protect SPF 30 - iS CLINICAL
    Best Seller

    Extreme Protect SPF 30

    Regular price $86.00
    Size: Net wt. 3.5 oz.e 100 g
    STEP 4: PROTECT

    Extreme Protect SPF 30

    HYDRATING, RESTORATIVE, UVA/UVB PROTECTION

    Regular price $53.00 – $86.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Youth Intensive Crème - iS CLINICAL Youth Intensive Crème - iS CLINICAL

    Youth Intensive Crème

    Regular price $256.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    Youth Intensive Crème

    AGE-DEFYING, HYDRATING, FIRMING

    Regular price $256.00 – $420.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • GeneXC Serum - iS CLINICAL GeneXC Serum - iS CLINICAL

    GeneXC Serum

    Regular price $185.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    GeneXC Serum

    PROTECTIVE, RESTORATIVE, AGE-DEFYING

    Regular price $114.00 – $185.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Copper Firming Mist - iS CLINICAL Copper Firming Mist - iS CLINICAL
    Award Winner

    Copper Firming Mist

    Regular price $45.00
    Size: 2.5 fl. oz. e 75 mL
    STEP 2: TREAT

    Copper Firming Mist

    AGE-DEFYING, REFRESHING, FIRMING

    Regular price $45.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Cream Cleanser - iS CLINICAL Cream Cleanser - iS CLINICAL

    Cream Cleanser

    Regular price $52.00
    Size: 4 fl. oz. e 120 mL
    STEP 1: CLEANSE

    Cream Cleanser

    DEEP-CLEANSING, MOISTURIZING, SOOTHING

    Regular price $52.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • C Eye Serum Advance+ - iS CLINICAL C Eye Serum Advance+ - iS CLINICAL

    C Eye Serum Advance+

    Regular price $75.00
    Size: 15 g e Net wt. 0.5 oz
    STEP 2: TREAT

    C Eye Serum Advance+

    Vitamin C Eye Serum to Brighten & Reduce Visible Signs of Aging

    Regular price $75.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Brightening Complex - iS CLINICAL Brightening Complex - iS CLINICAL

    Brightening Complex

    Regular price $166.00
    Size: Net wt. 1 oz. e 30 g
    STEP 2: TREAT

    Brightening Complex

    SAFE BRIGHTENING, HYDRATING, ANTIOXIDANT

    Regular price $166.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Brightening Serum - iS CLINICAL Brightening Serum - iS CLINICAL

    Brightening Serum

    Regular price $152.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Brightening Serum

    BRIGHTENING, REVITALIZING, SMOOTHING

    Regular price $90.00 – $152.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Youth Serum - iS CLINICAL Youth Serum - iS CLINICAL

    Youth Serum

    Regular price $174.00
    Size: 1 fl. oz. e 30 mL
    STEP 2: TREAT

    Youth Serum

    TIGHTENING, SMOOTHING, RESTORATIVE

    Regular price $174.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Extreme Protect SPF 40 - iS CLINICAL Extreme Protect SPF 40 - iS CLINICAL

    Extreme Protect SPF 40

    Regular price $92.00
    Size: Net wt. 3.5 oz. e 100 g
    Tint: Translucent
    STEP 4: PROTECT

    Extreme Protect SPF 40

    PROTECTIVE, BROAD SPECTRUM, WATER-RESISTANT FORMULA

    Regular price $92.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Youth Complex - iS CLINICAL Youth Complex - iS CLINICAL

    Youth Complex

    Regular price $172.00
    Size: Net wt. 1 oz. e 30 g
    STEP 2: TREAT

    Youth Complex

    TONING, AGE-DEFYING, TIGHTENING

    Regular price $172.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • NeckPerfect Complex - iS CLINICAL NeckPerfect Complex - iS CLINICAL
    Award Winner

    NeckPerfect Complex

    Regular price $120.00
    Size: Net wt. 1.7 oz. e 50 g
    STEP 2: TREAT

    NeckPerfect Complex

    TIGHTENING, SCULPTING, SMOOTHING

    Regular price $120.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Eye Complex - iS CLINICAL Eye Complex - iS CLINICAL

    Eye Complex

    Regular price $98.00
    Size: Net wt. 0.5 oz e 15 g
    STEP 2: TREAT

    Eye Complex

    Smoothing Eye Cream to Reduce the Look of Puffiness & Dark Circles

    Regular price $98.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Tri - Active Exfoliating Masque - iS CLINICAL Tri - Active Exfoliating Masque - iS CLINICAL

    Tri-Active Exfoliating Masque

    Regular price $104.00
    Size: Net wt. 4 oz. e 120 g
    STEP 2: TREAT

    Tri-Active Exfoliating Masque

    AGE-DEFYING, RESURFACING, SMOOTHING

    Regular price $104.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • LIProtect SPF 35 - iS CLINICAL LIProtect SPF 35 - iS CLINICAL

    LIProtect SPF 35

    Regular price $25.00
    Size: Net wt. 0.17 oz e 5 g
    STEP 4: PROTECT

    LIProtect SPF 35

    PROTECTIVE, NOURISHING, CONDITIONING

    Regular price $25.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • The Active Collection - iS CLINICAL The Active Collection - iS CLINICAL
    29% Savings

    The Active Collection

    Regular price $98.00
    (29% Savings)
    Size: Boxed Set

    The Active Collection

    Regular price $98.00
    (29% Savings)

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Hydra - Intensive Cooling Masque - iS CLINICAL Hydra - Intensive Cooling Masque - iS CLINICAL

    Hydra-Intensive Cooling Masque

    Regular price $105.00
    Size: Net wt. 4 oz. e 120 g
    STEP 2: TREAT

    Hydra-Intensive Cooling Masque

    REINVIGORATING, REFRESHING, SOOTHING

    Regular price $105.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • Youth Body Serum - iS CLINICAL Youth Body Serum - iS CLINICAL
    Award Winner

    Youth Body Serum

    Regular price $130.00
    Size: 6.7 fl. oz. e 200 mL
    STEP 2: TREAT

    Youth Body Serum

    HYDRATING, NOURISHING, PROTECTIVE

    Regular price $29.00 – $130.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details
  • PerfecTint Powder SPF 40 - iS CLINICAL PerfecTint Powder SPF 40 - iS CLINICAL

    PerfecTint Powder SPF 40

    Regular price $82.00
    Size: Boxed Set
    Tint: PerfecTint Ivory
    STEP 4: PROTECT

    PerfecTint Powder SPF 40

    TOTAL PROTECTION, HYDRATING, MATTE FINISH

    Regular price $82.00

    GIFT WITH PURCHASE: Daily Must-Haves Set ($112 value) with a $225+. Code SEPGIFT26. Details

iS Clinical products represent the intersection of pharmaceutical-grade science and luxury skincare — delivering clinically proven formulations trusted by professionals in 120+ countries. This complete collection brings together the full range of cleansers, treatment serums, moisturizers, sun protection, and specialty products within the Cleanse, Treat, Hydrate, Protect regimen.

Start with the Cleanse step, where Cleansing Complex prepares the skin for optimal absorption of treatment actives. Move to the Treat step with targeted serums like Active Serum and Pro-Heal Serum Advance+ to address specific complexion concerns. The Hydrate step seals in moisture with products like Reparative Moisture Emulsion, and the Protect step completes the regimen with Eclipse SPF 50+ for daily sun defense.

Beyond the core regimen, explore specialty categories including eye care, body treatments, and exfoliants for comprehensive results from head to toe. Every iS Clinical formulation is developed with botanically derived actives and backed by clinical research.

Find your ideal protocol with the skincare recommendation quiz, or explore our best sellers to discover the products professionals recommend most.